Menu
Land and oceans
White roofs could cool cities: study
Enzyme crystal helps crack HIV puzzle
Sugar sweetens decision making
Twilight zone secrets revealed
Astronomers spot asteroid collision
Algae master quantum mechanics
Protein 'ushers' key to beating malaria
Researchers spin artificial bee silk
New view of Pluto increases mystery
Cell's power packs came from within
Antarctic snow linked to WA dry
Termites inspire hydrophobic materials
Study shows why it's scary to lose money
Soil impact underestimated: climate study
Lack of oxygen forced fish's first breath
Harder Sudoku puzzles on the way?
Weed genes could help feed the world
Logging makes forests more flammable: study
Food crisis looms warn scientists
Tiny sensors track 'lost' objects
'Climategate' university orders review
'Plumbing' key to flowering success
New twist on solar cell design
Scientists set new temperature record
Tailored diet may slow down DNA damage
Mounting evidence on the effect of micronutrients on DNA damage calls for a re-evaluation of recommended dietary intake values, say researchers.

Professor Michael Fenech of CSIRO's Food and Nutritional Sciences Division in Adelaide lays out his argument in a paper accepted for publication in the journal American Journal of Clinical Nutrition.

DNA damage accumulates naturally as we age, but a lack or excess of antioxidants and trace elements, involved in DNA replication and repair, could exacerbate the problem.

Fenech says current recommended dietary intake levels (RDIs) for micronutrients are not defined in terms of preventing DNA damage - the fundamental basis of diseases such as cancer.

"RDIs are the minimum amounts needed to prevent diseases caused by nutrient deficiencies," says Fenech. "We now need to define optimal dietary reference values for DNA damage prevention."

"The issue is how we do this for genetic subgroups of people, because supplements of a particular nutrient may be beneficial for some and harmful to others".

Professor Lynn Ferguson, Head of Nutrition at the University of Auckland, agrees, likening nutrient profiles to shoes.

"You can't have a different range of shoes for everybody, but you could have a group of sports shoes in one corner and a group of designer heels in another," says Ferguson.

"What we might end up with is some less rigid recommended amount that is then individually optimised by more precise techniques."
Genome clinics

Fenech is currently investigating the use of biomarkers to develop personalised nutritional advice for "genome health".

For the last three years, Fenech and colleagues have been working with Adelaide's Reach 100 genome health clinic to analyse the amount of DNA damage in blood samples from approximately 200 patients.

They use a technique called the 'cytokinesis-blocked micronucleus' (CBMN) assay, pioneered by Fenech, to assess DNA damage.

Each person's results were combined with their medical history, to develop dietary and lifestyle advice that aims to reduce DNA damage.

The cost of the process is $1150 and is a labour-intensive and time-consuming process. But Dr Jane Alderman of the Reach 100 clinic believes it is essential for preventative health.

"Approximately a third of patients who were in the middle or higher risk group in terms of their DNA damage rates have had a significant improvement [four months later] with our suggestions," she says.

Alderman says it "is a pleasing result", but points out that the research is still in its early stages.

"At the moment we are only making recommendations based on the levels of vitamin B12, folate and lifestyle," she says.

"In the next few years we look forward to being able to use additional biomarkers to refine our recommendations so that we can advise on supplementation of other micronutrients."
Further research

The scientists have identified other biomarkers in the laboratory.

"The CBMN assay has proven to be more versatile than we originally thought", says Fenech. "There are now six biomarkers which measure three types of DNA damage, such as breaks, the rate of cell division and two forms of cell death".

The researchers believe segregating the type of DNA damage will yield further clues as to its cause. This could lead to intervention measures that could be used to improve genome health and prevent onset of disease.

"Ten years ago we didn't have the data or the methods to be able to do this, we are really just at the beginning", says Fenech.

Ferguson, whose research interest is Crohn's disease and Inflammatory Bowel Disease, hopes the technology may one day be used to stop genetically-prone infants from developing these disorders.

Print
Horny mother beetles fight for dung
Light-speed computing one step closer
Small asteroids 'just lumps of gravel'
Gene study reveals diverse gut zoo
Dinosaur extinction caused by asteroid: study
Study finds methane bubbling from Arctic
New view reveals Mars' icy history
Some nano-sunscreens 'come at a cost'
Dust bunnies could harbour toxic load
Aphid genome reveals its 'Achilles heel'
Tailored diet may slow down DNA damage
Scientist probe ballistic chameleon tongue
Moa eggshells yield ancient DNA
Toothbrush tech helps buses go green
Gene protects some Tassie devils from tumour
Smaller fish cope better with acidic water
Lunar mirror mystery solved
Parents give fewer bad genes than thought
Women on pill may live longer
Antarctic winds affect key ocean layer
Researchers uncover thalidomide mystery
Boost for evidence of early ocean
Ocean geoengineering may prove lethal
People leave unique 'germ print'
Rogue star on collision course
Butterflies 'fly early as planet warms'
Glaucoma may start in the brain
Tools push back dates for humans on Flores
Menu
Stem cell capsules to target broken bones
Ecstasy damages complex memory: study
Earliest animals flexed their muscles
Insomnia may shrink the brain: study
Experts call for 'resilience thinking'
Tutu's DNA could point to medical cures
Humble algae key to whale evolution
Happiness linked to healthy heart
Fewer cyclones, but more intense: study
Cosmic candles result of colliding stars
Flightless mosquitoes may curb dengue
Childhood poverty may leave its mark
Cautious response to technology strategy
Nanowire RAM to make ever-ready computers
Are non-smokers smarter than smokers?
There's iron in them thar Martian hills
'Shell Crusher' shark swam ancient oceans
Nanotechnology may tap into your mind
Small dogs originated in the Middle East
Brain 'hears' sound of silence
Swimmers 'may not understand' tsunami risk
Altruism surfaces on slow-sinking ship
Chile quake tops Haiti, but less deadly
Weedkiller 'makes boy frogs lay eggs'
Visit Statistics
http://google.com/

http://bing.com/

https://gepatit-info.top/

https://serdechnic.com/

https://buy-meds24.com/

https://dverirespekt.ru/

https://www.sribno.net/

https://undergroundcityphoto.com/

https://detskiezabolevaniya.com/

http://grafaman.ru/

http://innoslicon.com/html/product/index.htm

https://yginekologa.com/

https://yes-com.com/

https://www.baikaleminer.com/

https://bitmaein.com/shop

https://www.artdeko.info/

https://aerodizain.com/

http://xn--d1abj0abs9d.in.ua/

http://lider82.ru/

http://sta-grand.ru/

http://snabs.kz/

https://sky-mine.ru/

https://rybalka-opt.ru/

http://snegozaderzhatel.ru/

https://xn--e1aaajzchnkg.ru.com/

http://hit-kino.ru/

http://www.regionshop.biz/

https://xn--80aaafbn2bc2ahdfrfkln6l.xn--p1ai/

https://pp-budpostach.com.ua/

https://vykup-avto-krasnodar.ru/

https://gcup.ru/

https://mega-polis.biz.ua/

http://vanrise.com.ua/

http://infra-e.ru/

https://veterinariya.com/

https://ponosanet.com/

https://cariestop.com/

https://proartrit.com/

https://elonm.ru/

https://nakozhe.com/

https://spinanebolit.com/

http://zameskino.ru/

http://kinoprinc.ru/

http://pospektr.ru/

http://buypillsonline24h.com/

http://komputers-best.ru/

https://komp-pomosch.ru/